THINQURE20

RESEARCH STUDIES

“A Clinically proven Herbal Composition to reduce viral load in Covid 19 Infection”

Keywords: COVID19 , CORONA , RTPCR . VIRAL LOAD, BLACK FUNGUS, MUCORMYCOSIS, ENVELOPE NON ENVELOP VIRUS, INFLUENZA , PCR ,RT-qPCR

Abstract

Herbal composition shows remarkable reduction in viral load more than  in patients suffering from Covid 19 positive in to 4 days.  Pre and post treatment viral load detection done by Quantitative reverse transcription PCR (RT-qPCR).

Invitro studies indicates activity against Envelop and Non-envelop virus category MS2 &INFLUENZA respectively. Antifungal activity against one of species responsible for mucor mycosis.

Pharmacodynamics – Significantly reduces viral load in 3 to 4 days. As per molecular docking studies, phytochemicals like Piperine, , Zingiberene are antiviral . They are having activity   against covid spyke glycoprotein. as well as  ACE II receptor blocker so works as a prophylaxis.

Clinical trial – In Vivo Human – CTRI/2021/03/032471

STUDY TITLE – “A Non-Interventional, Retrospective, Observational study to analyze safety, efficacy and tolerability of THINQURE 20 in COVID-19 patients.”

Study Design – Single arm retrospective study of 30 patients diagnosed as Covid19 positive with mild to moderate symptoms. Objective to access decline in reduction of % Viral load in 96 hrs RTqPCR  (quantification of viral load ) method

  • Day1 – 2 tablets 500 mg each given by mouth to suck slowly till dissolve completely. Followed by 1 tab 4 hrly. Strict warning for tablet, not to chewing, crushing or swallowing.
  • Day 2, 3 4, 1 tab tablet 4 hrly .
  • Nasopharyngeal swab taken 24 hrly . Samples were sent to NABL accredited laboratory for RTqPCR (to quantify and get individual patients viral load)

Outcomes

  • Mean percentage reduction in viral load for all patients was observed to be 75.4 %, where the minimum reduction was observed to be 59.3 %, while maximum reduction in viral load was observed to be 100 %. Thinqure 20 is observed to be safe and effective in controlling viral load in COVID-19 patients. P-value. Change from baseline to end of study visit is <.0001
    • Decline in Viral Load was observed to be more than 90% for 22 patients
    • Decline in Viral Load was observed to be more than 70% for 6 patients

Viral Load

The treatment with Thinqure 20 for 5 days significantly (p<0.001) reduced the viral load in the Covid 19 Patients when compared with viral load before treatment

Non Clinical Study – In Vitro (Antiviral & Antifungal)- Study conducted in Mumbai NABL & GLP certified laboratory.

Outcomes

  • Antiviral activity against Non Envelop virus -Herbal formulation – 50µl has shown 85.00% reduction of MS2 Bacteriophage as surrogate virus in 4 hours per standard ASTM E 1052: 2020
  • Antiviral activity against Envelop virus -Herbal formulation – 50µl has shown 85.00% reduction of INFLUENZA as surrogate virus in 4 hours ASTM E 1052: 2020
  • Antifungal activity – Herbal formulation Herbal formulation 50mg/ml has shown reduction 96% reduction of test fungus viz. Mucor racemosus in 1 hour and 4 hours when analysed as per ASTM E 2315 – 16 Method.

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Thinqure20 – Safety and worldwide acceptance of herbal composition

  • This formulation is referred in Ayurvedic textbooks accepted by AYUSH. Such textual compositions are safe and directly can go for Phase IV / PMS studies.
  • Individual as well as combined ingredients are in use since last three thousand years.
  • All ingredients are FSSAI listed referred in API (Ayurvedic pharmacopeia of India) with GRAS listed

 Published Papers –

  • Paper is ready for publication. Will be published soon in peer review journal.

 

PATENT: – Primary specifications filed   as a “HERBAL COMPOSITION FOR COVID 19 INFECTION”

SUMMARY:-THINQURE20 is a herbal composition influences by Ayurvedic texts showing excellent antiviral activity against Covid and other respiratory virus infections. Also showing activity against one of the species responsible for mucormycosis.

A product of THINQ Pharma-CRO Limited 

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Disclaimer: Please note that the information provided is for the THINQURE 20 product information . Refer to your local government and/or health organizations for the most accurate and up to date information.